Ibuprofen, characteristics and side effects

The ibuprofen It is a non -steroidal anti -inflammatory (NSAIDs) that belongs to the subgroup of drug derived from propionic acid. Its use is effective in treating pictures that are inflammation.

However, this medicine is also very effective for other conditions, thanks to its analgesic and antipyretic action.

In the beginning, the ibuprofen It was the first drug derived from phenylpropionic acid And its great success was what promoted the development of other compounds such as phenoproxen, naproxen, ketoprofen, oxaprozine, flurbiprofen, among others, although ibuprofen remains the most clinical use.

In turn, it is one of the molecules that has been studied the most over the years and every day its popularity charges.

The effectiveness of this drug has been rigorously evaluated, so, today many doctors manage it knowing very well their behavior response.

Some of their presentations are sold in pharmacies with medical prescription, while others are free sale.

Content

• Ibuprofen, an effective compound for various conditions
• The surprising beginnings of ibuprofen
  • Ibuprofen administration complications
  • Other side effects are as follows:
  • Bibliography

Ibuprofen, an effective compound for various conditions

Certain conditions with which ibuprofen can be treated are those in which pain or inflammation is present.

Well, This drug acts relief, characterized by the degradation and inflammation of the coating of the joints, respectively.

Other conditions that also yield with the intake of this drug are the minor or moderate pain, present before or during the menstrual period.

Likewise, the ibuprofen that can be acquired without medical prescription is used to Calm headaches, decrease fever, relieve muscle aches, Dolores on the teeth, back, discomfort causes by the common cold, among others.

It should be noted that, in some cases, paracetamol can be more appropriate than ibuprofen.

In any case, ibuprofen has effectiveness because it stops the production of the substance that generates pain, inflammation and fever in the body, given that its effects act on the peripheral and central nervous system.

The surprising beginnings of ibuprofen

Ibuprofen is a derivative whose beginnings are surprising, because, as Dr. Juan Pablo García points out -written to the Department of Pharmacology at the University of Montevideo, Uruguay-, The Data Drug Research Program since 1950.

In the pharmacotherapeutic review of ibuprofen, Garcia indicates that at this time, what was intended was the development of a “super aspirin” that could calm the pain of rheumatoid arthritis.

Thus, in 1964 there were several promising compounds, but that of ibuprofen was selected to move on to the next phase, clinical experimentation.

After two years passed, its use was approved and introduced into the British market. By 1972 the pediatric formulas were also approved.

In the year of 1974 he was accepted in the United States, where his security and high efficacy profile had a good reception.

So that, in Between 1983 and 1984, Ibuprofen obtained free sale permit for adults, pointing out a dose of 1200 mg as maximum per day, ending up being installed in the British and North American market. Subsequent success already speaks for itself.

Ibuprofen administration complications

Although ibuprofen is very effective in the mentioned paintings, it is also necessary to clarify that can cause severe complications So its use must be responsible and under medical supervision.

Among the complications that the drug can cause, there are those considered serious, such as hemorrhages, perforations and death, especially in the population of people with more than 75 years, or who have a history of ulcer or gastrointestinal diseases.

Like the rest of the NSAIDs, Ibuprofen can cause ulcers, gastric erosions, bleeding and sudden death caused by gastrointestinal bleeding.

Likewise, they can trigger other types of complications, such as renal or cardiovascular. Acute renal failures can be accelerated after the administration of NSAIDs in elderly patients.

Those who have a medical history for acute rhinitis, nasal polyps or asthma, can also be affected by Broncoospasm.

Other side effects are as follows:

• Diarrhea;
• Constipation;
• Dizziness;
• Abdominal distension, or gases;
• Nervousness;
• Difficulty breathing;
• Rash;
• Fever;
• Weight gain;
• Inflammation in the ankles, abdomen, legs or feet;
• Urticaria
• Face in the face, eyes, lips, throat, tongue, hands;
• Fatigue;
• Nausea;
• Blurry vision;
• Confusion and aggressiveness.

In addition to those indicated, reactions can also occur due to hypersensitivity. It is because of that, Medical staff can suspend treatment with this NSAIDs before the first sign of cutaneous eruption or mucosa injuries.

While in the same way that ibuprofen has good acceptance and enjoys popularity today, it is also that this drug must be administered by a doctor and ingest responsibly.

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Bibliography

• Aguado, i. C., López, i. J., Pinilla, m. L. C., Garcia, i. C., Bengoechea, p. B., Fernández, m. B., & Contreras, J. R. (2005, February). Ibuprofen and paracetamol efficacy as antitermal. In Annals of Pediatrics (Vol. 62, no. 2, pp. 117-122). Elsevier Doyma.
• Galán Martínez, L., Osorio Acevedo, to., López Medina, A. Yo., Álvarez Collazo, J., & Álvarez, J. L. (2010). Cardiovascular actions of ibuprofen. Cuban Magazine of Biomedical Research, 29(3), 331-338.
• Garcia, J. (2007). Ibuprofen. Trends.
• Villalva-Rojas, or., Great-Fortíz, m., Ortiz, j., ISASI, J., Yantas, d., & Fiestas, V. (2007). Bioequivalence study of generic ibuprofen 400mg tablets. Peruvian Magazine of Experimental Medicine and Public Health, 24(4), 356-362.